Markers of glucagon resistance improve with reductions in hepatic steatosis and body weight in type 2 diabetes

Abstract Context Hyperglucagonaemia may develop in type 2 diabetes due to obesity-prone hepatic steatosis (glucagon resistance). Markers of glucagon resistance (including the glucagon-alanine index) improve following diet-induced weight loss, but partial contribution lowering versus body is unknown. Objective To investigate dependency loss a reduction on markers diabetes. Design and setting A post-hoc analysis from two previously published randomized controlled trials. We investigated effect maintenance (study 1: isocaloric feeding) or 2: hypocaloric feeding), both which induced reductions steatosis, sensitivity, including index measured using validated ELISA metabolomics 94 individuals (n=28 study 1; n=66 2). Participants were 6-week conventional (CD) carbohydrate-reduced high-protein (CRHP) diet within feeding-interventions. Individuals with overweight obesity Results By design, was greater after compared feeding, diets caused similar allowing us impact reducing without clinically relevant resistance. The improved hypocaloric, not isocaloric, independently macronutrient composition. Conclusion Improvements depend patients